Dr. Mark Pegram is the Suzy Yuan-Huey Hung Professor of Medical Oncology at the Stanford Cancer Institute. He currently serves as the Associate Director of Clinical Research at the Stanford Comprehensive Cancer Institute (SCCI), and Director of the Breast Oncology Program at Stanford.
He also serves as the Associate Dean for Clinical Research Quality at the Stanford University School of Medicine. In collaboration with Dr. Dennis Slamon at UCLA, and scientists at Genentech, Inc. in South San Francisco, CA, Dr. Pegram played a significant role in the pre-clinical and early clinical development of trastuzumab (Herceptin®) for the treatment of HER2-positive breast cancer. In 2012, he was recruited to the SCCI from the Sylvester Comprehensive Cancer Center at the University of Miami School of Medicine, where he served as the Associate Director for Clinical Research, and acting Division Chief of Hematology/Oncology for a faculty of over 70 researchers.
Pegram has chaired the U.S. Department of Defense Breast Cancer Research Program panel, and is the recipient of the NCI Director’s Service Award, the Sylvester Outstanding Cancer Research Award, the Hope Award from the HERS Breast Cancer Foundation, and is a Fellow of the Breast Cancer Research Foundation. His research focuses on new therapeutic strategies targeting HER2-positive breast cancers.
Dr. Pegram was the lead author on the papers describing pre-clinical synergy between multiple chemotherapeutics and trastuzumab, and the first phase II clinical trial of trastuzumab plus chemotherapy. In addition, he was the senior author of the pivotal trial of letrozole plus lapatinib – leading to an FDA approval, and co-author of the pivotal trials of trastuzumab plus chemotherapy, and T-DM1, both published in the New England Journal of Medicine, and leading to FDA approvals.