SENIOR SCIENTIST, IN VIVO PHARMACOLOGY

Rubedo Life Sciences is a biotechnology company with active research programs related to age-related diseases with a focus on fibrosis and respiratory disorders.  We are seeking a motivated and dynamic Senior Scientist to help build the capabilities needed for translational research and development, advancing the discovery of molecular targets and therapeutics for age-related pathobiologies, including fibrosis. The initial focus will involve respiratory disorders and a working knowledge of respiratory disease models is desired. The successful candidate will be an experienced drug-discovery scientist acting as the in vivo lead on various programs. This involves directing our team of in vivo scientists and collaborating with a cross-functional team of experts and working with CRO’s to facilitate successful advancement of programs. 

Responsibilities include:

  • Employ drug discovery principles while guiding programs through animal model development, proof of concept in validated efficacy models, pharmacokinetic studies and lead-optimization
  • Interpret data and assist in understanding PK/PD relationships
  • Design, conduct and manage experiments related to the discovery of therapeutic drug mechanisms targeting cellular senescence and age-related diseases
  • Analysis of data, and preparation of associated documentation and reports
  • Presentation of experimental results at internal meetings and scientific conferences
  • Develop protocols and maintain detailed documentation of procedures
  • Train and supervise scientists and research associates

Minimum Requirements:

  • D. or equivalent in Biology, Physiology, Pharmacology, Biochemistry, Immunology, or related discipline
  • Five or more years of relevant industry experience
  • Experience in the study of chronic diseases in one or more of the following disease areas: fibrotic, respiratory, metabolic, inflammatory or other age-related diseases
  • Proven ability to solve complex problems by undertaking innovative approaches and applying state-of-the art technologies
  • Demonstrated experience in moving programs across stage-gates

Preferred Experience And Skills:

  • Established knowledge base in fibrosis, or at least one aspect of age-related disease biology
  • Experience with pulmonary fibrosis preclinical models
  • Experience selecting and managing CROs
  • Demonstrated experience in project leadership
  • Excellent communication skills and ability to work in multidisciplinary project teams
  • Actively seeks and embraces feedback with the goal of continuous performance improvement

Environmental Conditions / Physical Demands:

Physical:Lifting up to 20 lbs occasionally, standing, bending, repetitive movement, etc.
Environmental:Exposure to wet lab environment, blood borne pathogens, and toxic or caustic chemical or reagents
Work Location:Sunnyvale, CA, USA